Discoveries

=Discoveries= 1. With excess ethanol, 4-chlorobenzaldehdye forms a hemiacetal with about 10% conversion at equilibrium, which occurs within 30 min at 25C. (CRSEXP001 ) **JC Bradley** 2. With excess methanol, 4-chlorobenzaldehdye forms a hemiacetal with about 20% conversion at equilibrium, which occurs within 60 min at 25C. (CRSEXP002 ) **JC Bradley** 3. When D2O in the external co-axial NMR tube chamber is set to 4.8 ppm, pure acetone in the inner chamber reliably appears at 3.1 ppm (for example from EXP026) when clearly it should be at 2.05 (based on published values of acetone-d5 residue). This issue must be resolved to understand the implications for CRS since it depends so heavily on chemical shifts. **JC Bradley** 4. It is possible for hemiacetal hydroxyl coupling to be observed even when the alcoholic hydroxyl of the solvent does not. This would imply that H exchange for a hemiacetal is slower than an alcoholic hydroxyl. CRSEXP001 **JC Bradley**