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=Chemical Rediscovery Survey=

Contacts
[|Jean-Claude Bradley] (PI, Drexel University) (ResearchGate Profile ) Andrew Lang (co-PI, Oral Roberts University) (ResearchGate Profile ) [|Cuepil Kevin Choi] (Student, Drexel University) Matthew McBride (Student, Drexel University) Kayla Gogarty (Student, Drexel University) [|Andrew Buss] (Student, Drexel University)

About
The purpose of the Chemical Rediscovery Survey is to simply report what happens when (mainly simple organic) chemicals are mixed under controlled conditions. The behavior of these mixtures is primarily reported by H NMR using a co-axial system where the deuterated solvent needed to lock the NMR signal is placed in an outside chamber, thus preventing it from chemically interacting with the mixture under study. Since homogeneous solutions are typically required for high quality spectra and reliable integration, when insolubility events occur the experiments are stopped and the outcome reported. The ultimate aim of the survey is to uncover unexpected and potentially useful chemical behavior upon a systematic search of as much of the mole fraction hyperspace of a collection of simple and primarily safe chemicals. Although concepts such as mechanisms, kinetics, the solute/solvent paradigm and other basic organic chemistry basic theory will be considered when potentially useful in reaction design, these will not be systematically considered a priori in the the selection of which chemical mixtures to explore. We believe that this bias has proven to act as a powerful conceptual barrier to attempting types of experiments which may lead to the discovery of new useful chemical behavior.

Experiments
CRSEXP001 4-chlorobenzaldehyde and ethanol (**Cuepil**) CRSEXP002 4-chlorobenzaldehyde/methanol and 4-chlorobenzaldehyde/ethanol (**Cuepil**) CRSEXP003 4-chlorobenzaldehyde/water and 4-chlorobenzaldehyde/ethylene glycol in acetonitrile solvent (**Cuepil**) CRSEXP004 octanoic acid and water (**Cuepil**) CRSEXP005 octanoic acid saturated with water and vice versa (**Cuepil**) CRSEXP006 ethylene glycol and 4-chlorobenzaldehyde (**Cuepil**) CRSEXP007 4-chlorobenzaldehyde and ethanol (**Cuepil**) CRSEXP008 choline chloride and urea green eutechtic solvent (**Cuepil**) CRSEXP009 4-chlorobenzaldehyde ethylene glycol acetal through reflux (**Cuepil**) CRSEXP010 4-chlorobenzaldehyde ethylene glycol acetal extraction through silica plug (**Cuepil**) CRSEXP011 4-nitrobenzaldehyde ethylene glycol acetal creation through reflux and extraction with benzene (**Cuepil)** CRSEXP012 4-chlorobenzaldehyde ethylene glycol acetal extraction attempt with rotary device and benzene water/ benzene ethylene glycol azeotropes (**Cuepil**) CRSEXP013 4-chlorobenzaldehyde and ethanol acetal attempt (**Cuepil**) CRSEXP014 4-chlorobenzaldehyde and ethylene glycol (**Cuepil**) CRSEXP015 4-chlorobenzaldehyde and ethylene glycol 1:1 ratio reflux (**Cuepil**) CRSEXP016 4-chlorobenzaldehyde and diethylene glycol (**Cuepil**) CRSEXP017 4-chlorobenzaldehyde and ethanol kinetic study (**Cuepil**) CRSEXP018 4-chlorobenzaldehyde and ethylene glycol, recrystallization attempt (**Cuepil**) CRSEXP019 4-nitrobenzaldehyde and methanol to see if hemiacetals are detectable in GCMS (**Cuepil**) CRSEXP020 4-chlorobenzaldehyde and ethylene glycol with water kinetic study (**Cuepil**) CRSEXP021 4-chlorobenzaldehyde and ethanol to see if acetals form (**Cuepil**) CRSEXP022 4-chlorobenzaldehyde and methanol to see if acetals form (**Cuepil**) CRSEXP023 4-chlorobenaldehyde and ethanol with 4-chlorobenzoic acid purposely added (**Cuepil**) CRSEXP024 water and methanol (**Cuepil**) CRSEXP025 E coli (**Kayla Gogarty**) CRSEXP026 acetone and propanoic acid (**Kayla Gogarty**) CRSEXP027 Acetone and piperidine (**Matthew McBride**) CRSEXP028 prepatory run of isolating 4-chlorobenzaldehyde ethylene glycol acetals (**Cuepil**) CRSEXP029 D2O HNMR shift using the coaxial NMR tube system (**Matthew McBride**) CRSEXP030 Rotovap ethanol 4-chlorobenzaldehyde (**Cuepil**) CRSEXP031 isopropyl and 4-chlorobenzaldehyde (**Cuepil**) CRSEXP032 Acetone, Ethanol, Methanol and D2O HNMR shift using the coaxial NMR tube system with D2O and CDCl3 as the reference solvents (**Matthew McBride**) CRSEXP033 Acetone and Propylamine (**Kayla Gogarty**) CRSEXP034 Acetone, Water, and Propylamine (**Kayla Gogarty**) CRSEXP035 Salicylaldehyde and Ethanol, Methanol, Benzene and Propylamine (**Matthew McBride**) CRSEXP036 4-chlorobenzaldehyde ethylene glycol prep run with wash (**Cuepil**) CRSEXP037 piperonal and methanol(**Cuepil**) CRSEXP038 NMRs of various wines (**Grace Petrecca and Matthew McBride**) CRSEXP040 Acetic Anhydride and Phenanthrene-9-Carboxaldehyde (**Kayla Gogarty**) CRSEXP041 Acetic Anhydride and Piperonal (**C. Jared Miller**) CRSEXP042 Acetic Anhydride and Heptylamine (**Kayla Gogarty**) CRSEXP043 Acetic Anhydride and Cyclohexanol (**Kayla Gogarty**) CRSEXP044 Acetic Anhydride and Ethanol (**Andrew Buss and Kayla Gogarty**) CRSEXP045 Acetic Anhydride and Methanol (**Kayla Gogarty**) CRSEXP046 acetonitrile in applied electric field via copper wire electrodes (**Andrew Buss**) CRSEXP047 acetonitrile in applied electric field via copper wire electrodes (**Andrew Buss**) CRSEXP048 acetonitrile in applied electric field via copper plate electrodes (**Andrew Buss**) CRSEXP049 acetonitrile in applied electric field via graphite electrodes (**Andrew Buss**) CRSEXP050 Acetic Anhydride, Ethanol, and Dimethylformamide (**Kayla Gogarty**) [|List of Chemicals] (**Kayla Gogarty**)